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Most common diseases and quantitative traits are heritable: determined in part by genetic variation within the population. The inheritance is typically polygenic in that combined effects of variants in numerous genes, plus nongenetic factors, determine outcome. The genes influencing common disease and quantitative traits remained largely unknown until the implementation in 2006 of genome-wide association (GWA) studies that comprehensively surveyed common genetic variation (frequency >5%). By 2010, GWA studies identified >1,000 genetic variants for polygenic traits. Typically, these variants together account for a modest fraction (10%–30%) of heritability, but they have highlighted genes in both known and new biological pathways and genes of unknown function. This initial effort prefigures new studies aimed at rarer variation and decades of functional work to decipher newly glimpsed biology. The greatest impact of GWA studies may not be in predictive medicine but rather in the development over the next decades of therapies based on novel biological insights.

  • Sales Rank: #2188049 in eBooks
  • Published on: 2012-12-06
  • Released on: 2012-12-06
  • Format: Kindle eBook

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Russian Fairy Tales (The Pantheon Fairy Tale and Folklore Library), by Aleksandr Afanas'ev

Translated by Norbert Guterman
Illustrated by Alexander Alexeieff


In this most comprehensive collection of classic Russian tales available in English we meet both universal fairy-tale figures—thieves and heroes, kings and peasants, beautiful damsels and terrifying witches, enchanted children and crafty animals—and such uniquely Russian characters as Koshchey the Deathless, Baba Yaga, the Swan Maiden, and the glorious Firebird. The more than 175 tales culled from a centuries-old Russian storytelling tradition by the outstanding Russian ethnographer Aleksandr Afanas’ev reveal a rich, robust world of the imagination that will fascinate readers both young and old.

With black-and-white drawings throughout
Part of the Pantheon Fairy Tale and Folklore Library 




From the Trade Paperback edition.

  • Sales Rank: #361239 in eBooks
  • Published on: 2013-01-02
  • Released on: 2013-01-02
  • Format: Kindle eBook

Review

“Rambunctious, full-blooded, and temperamental, these stories are tense with action, magical, and human. They are gorgeous.”
—Eudora Welty
 
“The oral folk tradition in Russia was truly a magic spring [that] flowed inexhaustibly, reviving, consoling, and enlightening all who partook of it . . . These stories have an ingenuity that marks them as uniquely Russian.”
—Time
 
 “A beautiful book. I recommend it to all readers, young and old, who are interested in the folktale and its unique qualities.”
—Isaac Bashevis Singer, The New York Times Book Review

“Luckily someone garnered these jewels before they were lost [and] bound them into one volume before they disappeared . . . It is filled with action, magic, and humanity.”
—St. Louis Globe-Democrat

Language Notes
Text: English, Russian (translation)

From the Inside Flap
Nearly 200 characteristic and colorful traditional folk and fairy tales are brought together in the only comprehensive edition available in English. Of the original 1945 edition, Eudora Welty wrote, "These Russian tales are rambunctious, full-blooded and temperamental. They are tense with action, magical and human, and move in a kind of cyclone of speed....These tales are gorgeous."

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76 of 78 people found the following review helpful.
A huge collection
By Stephen Arkanell
What the Grimm Brothers did for fairy tales in Germany, Afanas'ev did for Russia. Over the course of his lifetime(1826-1871), he collected countless of these wonderful little stories from common folk, just as the Grimms did. This collection contains stories of adventure and enchantment, animal fables and more. Included are stories of Vasilissa and Baba Yaga, the witch whose house was built on chicken feet, and the famous story of the giant turnip. There's even some stories about vampires. But be prepared, this book is huge! And every bit of it distinctly Russian.

63 of 67 people found the following review helpful.
Ian Myles Slater on: Classic Tales, Enduring Translation
By Ian M. Slater
I have owned since 1975 a copy of an earlier, hardcover, Pantheon reprint edition of this superb collection, which was originally published in 1945. I have used it for both light reading and for serious study (while in courses on Baltic and Slavic Folklore and Folktale Studies). The selection and translation of stories both seem first-rate. (For the latter, I have had to rely on the opinions of those who actually read Russian, instead of just having studied it in school.) The accompanying illustrations are properly enchanting -- and only occasionally are placed where they give away the point of the story.

The only real drawback is that it is still merely a selection from about three volumes (depending on the edition you prefer) of "skazki." This is the Russian term for oral tales of marvels, adventures, and misadventures, equivalent to the German "Maerchen." In both cases, the English term "Fairy Tale" is the conventional, but not really adequate, translation. (As usual in large collections, only a handful of tales concern anything like fairies.) One of the requirements for the selection seems to have been that the tales chosen should be acceptable to American parents in the 1940s, but otherwise the considerable variety of the original seems to have been largely preserved. The suggested reader age of "9 to 12" conceals the pleasure that adult readers with interests in folklore or Russian culture will derive from the volume. Fortunately, they may be lead to it by the fine supplementary material at the end, although this is now half a century old.

Afanas'ev (various transliterations) was one of the many nineteenth-century collectors inspired by the Grimms,. By most accounts he was one of the most responsible, even though his practices of recording and documenting texts are hardly up to modern standards. (Neither were those of the Grimms, for that matter.) The main collection from which this was excerpted was the sourcebook for Vladimir Propp's "Morphology of the Folktale," a key work in modern folktale studies, but as Roman Jakobson (yes, the Structural Linguist) points out in his commentary to this collection, the book had already established itself as a gem of Russian literature, an inspiration and resource for poets.

51 of 55 people found the following review helpful.
What a fun book!
By Kendal B. Hunter
Fairy tales get us into the psyche of a culture. Americans see themselves as Paul Bunyan and Johnny Appelseed, conquoring the frontier. This book introduces us to the Russian psyche. It shows us how they look at things--the world, society, life, family, and government.
Some of the stroies are charming, such as the fabel of the Turnip and the Honey-pot. Other stories made absolutley no sense. But I had fun trying to crack these weird nuts.
I enjoyed the translation. It is not as energetic as Seamus Heaney, or J. B. Phillipws, but it is readable, athough you realize that you are reading a translation.
C. S. Lewis, in his preface to "The Lion, the Witch, and the Wardrobe," mentions that as children we read fairy tales, then we outgow them. Then, as adults, we come back to these stories and read them with different eyes. I had that experince with this book.

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Sabtu, 25 April 2015

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Over the next few years, the Connecting for Health IT programme for the NHS in England is due to implement electronic prescribing systems at all hospitals in England. Furthermore, the other UK countries are likely to follow suit with clinical IT implementation programmes, and these developments will generate interest in electronic prescribing at European and international level. There is therefore likely to be an exponential growth in the significance of electronic prescribing over the next ten years. Principles of Electronic Prescribing discusses the basic principles of design and implementation of secondary care electronic medicines management systems, and how their design and configuration can impact on benefits realization, hospital workflow and clinical practice.

  • Sales Rank: #3605537 in eBooks
  • Published on: 2012-06-05
  • Released on: 2012-06-05
  • Format: Kindle eBook

Review

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"This book on all aspects of neurotrauma and critical care of the spine is needed in face of the constant development of critical care and surgical strategies for spinal cord injury. … Neurosurgeons, neurologists, anesthesiologists, critical care physicians, and neurointensivists are the main audiences for this book. … This is a good book on the surgical management of spinal cord injury. … it is a good reference for neurosurgeons, neurologists, and intensivists who want a brief update on classification and management."(Celso Agner, Doody’s Review Service, November, 2008)

From the Back Cover

Electronic prescribing (EP) is a complex discipline, the success of which relies on the successful interplay of system design, data support and clinical practice. It represents the use of electronic systems to facilitate and enhance communication of a prescription or medicine order, and improves legibility and completeness of prescriptions, improves availability of electronic decision support tools at the point of prescribing, enables a comprehensive audit trail, and reduces medication-related errors. These benefits are far-reaching in significance, both in terms of their effects on risk management and risk reduction and their financial impact. Given the likely growth of interest in electronic medicines management, this discussion of relevant design issues and their impact is timely.

Electronic Prescribing: Principles and Practice discusses the basic principles of the design and implementation of secondary care electronic medicine management systems, and how they impact hospital workflow and clinical practice. It documents the key aspects of EP systems for use in secondary care, including design issues, data support, benefits and the ways in which electronic medicines management systems can optimize clinical and professional practice.Because of the significance of electronic medicines management to the whole medical supply chain, and the various stakeholders involved in the IT implementations, the book will be of interest to a wide range of professionals, from hospital pharmacists and prescribing physicians to health system managers and informaticians.

About the Author

After qualifying in pharmacy and working as a hospital pharmacist, Stephen Goundrey-Smith subsequently studied Information Science at City University, London. He has worked as a medical information officer in the pharmaceutical industry, and as an analyst on electronic prescribing, pharmacy and medicines management software in the IT industry. He currently manages SGS PharmaSolutions, a specialist consultancy dealing in pharmacy informatics and contract professional communications for the international pharmaceutical industry. He has published a number of papers on clinical and information science issues, including, recently, the first comprehensive review of electronic prescribing system design and experience in the UK. He has also contributed to the recent Connecting for Health consultation on electronic prescribing requirements.

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  • Published on: 1948
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  • 310 pages

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The challenge of teaching classical literature has been made easy! Whether you're a teacher in a classroom, home school mom, or leading a small group, these studies shake off the dust and make these novels relevant to the 21st Century reader. More importantly they teacher the reader the relevance of scripture in all areas of life. No more namby-pamby Christians that get blown out of the water in their first college class. We endeavor to help equip people to face the challenges of life head on with the sword of the spirit (Word of God) firmly in their hands.
Classical Literature Study Guides' products are easy to use. There is a reader's section of questions for each chapter. A brief teaching on developing a well constructed essay using quotes from the novel as well as from Scripture is included.
The Teacher's section includes a guide to grading as well as a set of sample answers to the questions. In Literature, there are often more than one correct answer. Our answers are provided to encourage discussion and thought.
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  • Sales Rank: #1066198 in eBooks
  • Published on: 2012-12-07
  • Released on: 2012-12-07
  • Format: Kindle eBook

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Selasa, 21 April 2015

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String theory is one of the most active branches of theoretical physics and has the potential to provide a unified description of all known particles and interactions. This book is a systematic introduction to the subject, focused on the detailed description of how string theory is connected to the real world of particle physics. Aimed at graduate students and researchers working in high energy physics, it provides explicit models of physics beyond the Standard Model. No prior knowledge of string theory is required as all necessary material is provided in the introductory chapters. The book provides particle phenomenologists with the information needed to understand string theory model building and describes in detail several alternative approaches to model building, such as heterotic string compactifications, intersecting D-brane models, D-branes at singularities and F-theory.

  • Sales Rank: #2155687 in eBooks
  • Published on: 2012-02-09
  • Released on: 2013-07-24
  • Format: Kindle eBook

Review
ENDORSEMENT:
"... invaluable as a textbook for curious students, and a reference volume of lasting value for experts working in the field. If, as many of us hope, the LHC era reveals new clues linking particle physics to string-scale physics, acquaintance with the material in this volume may well provide crucial tools for exploring and exploiting those links."
Shamit Kachru, Stanford University and SLAC

ENDORSEMENT:
"A clear exposition of the main ideas and ingredients necessary to connect string theory to the real world. An essential toolkit for the string theory model builder"
Juan Maldacena, Institute for Advanced Study, Princeton

ENDORSEMENT:
"...invaluable and comprehensive material for graduate students entering the field, for non-string theorists who want to expand their research projects but also as the best authoritative source of information for active string theorists. This will be the standard reference on this active field for years to come."
Fernando Quevedo, Professor of Theoretical Physics, DAMTP, University of Cambridge and Director ICTP, Trieste

ENDORSEMENT:
"The scope of this book is impressive, covering all the major developments in the construction of compactified string theories. As an introduction to string theory it is excellent and, as a tool for constructing realistic models, unmatched. Essential reading for all those wishing to study string theory in depth and an invaluable reference for those already expert in the field."
Graham Ross, University of Oxford

"This is an excellent book which will introduce the reader to the main topics of relevance in string phenomenology today, and it is also a very good reference book. As well as wide coverage, the authors have included many helpful comments and discussions about specific methods and models. In addition, the production of the book is of very high quality, making it enjoyable to read. Naturally the field is continually progressing so this book will not always be cutting-edge, but I think it will likely remain a very useful introductory text for many years to come."
Douglas J. Smith, Mathematical Reviews

About the Author
Luis E. Ibáñez is Professor of Theoretical Physics at the Universidad Autónoma de Madrid and member of the Instituto de Física Teórica-UAM/CSIC. One of the world leaders in physics beyond the Standard Model of particle physics, he has made important contributions to the construction of the supersymmetric Standard Model and superstring phenomenology.

Angel M. Uranga is Research Professor at the Consejo Superior de Investigaciones Científicas at the Instituto de Física Teórica-UAM/CSIC. He is one of the leading young string theorists working in the construction of models of particle physics, in particular due to his contribution on the use of D-branes to build realistic brane-world models.

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'DEEPLY MOVING, THIS IS AN UNUSUAL AND HIGHLY READABLE NOVEL'
(Yorkshire Post)

When Rebecca Sheldon married George Ludbury, she found herself at war with his snobbish, possessive and malicious family as well as with the hypocrisy of the Edwardian society in which she lived.

This novel explores the insularity of country people in the English midlands between the years 1888 and 1923 and vividly captures the patriotic fervour on the Home Front during the first world war. Above all though, we follow Rebecca who, with grace and good humour, is fighting her own private battles, her own quiet war.

'HUMOUR MAKES THIS MORE THAN AN EVERYDAY STORY OF COUNTRY FOLK' (Irish Times)

'COMPULSIVELY READABLE ' (The Lady)

  • Sales Rank: #668186 in eBooks
  • Published on: 2012-12-05
  • Released on: 2012-12-05
  • Format: Kindle eBook

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2 of 2 people found the following review helpful.
Very Quiet War
By R. Hunter
I persisted through this one because i like to finish what I started. This is a long story about a strange family that never really grabbed me. It wasn't horrible. I just never really got the point. Sometimes the timeline seemed a little off kilter, as well. Not one I'd read again, but not really sorry I read it either.

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Senin, 20 April 2015

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The leader guide provides two kinds of information: (1) suggestions for weekly group sessions; (2) information to enhance leadership skills, to support group building and maintenance, and to make effective use of the CHRISTIAN BELIEVER components.

A one-page session plan for each of the thirty weeks follows a set procedure with an amount of time indicated for each step.  Each session plan provides guidance for group activities that make use of the daily preparation members have made, and questions for discussion.  Group activities are designed to focus on content and help persons connect Scripture, doctrine, believing, and living.


The leader guide assumes that:



  • The leader makes the same preparation for the weekly group session as the other members of the group.

  • Study and discussion in the weekly session is done mainly in small groups.

  • The leader both guides the process and participates with other group members in the small-group study and discussion.

  • The leader is not an information-giver or lecturer.

  • The leader and the group members have access to the same content for study and discussion—the assigned Scripture, selections from the book of Readings, the study manual, and the video presentations.

  • A study of CHRISTIAN BELIEVER can renew lives and congregations.

  • Sales Rank: #2607788 in eBooks
  • Published on: 2010-09-01
  • Released on: 2010-09-01
  • Format: Kindle eBook

Most helpful customer reviews

1 of 1 people found the following review helpful.
A nice concise overview of Christian beliefs and practices
By Ann Mann
A nice concise overview of Christian beliefs and practices. Works best when used with the study guide in a small group.

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Movement Disorder Emergencies: Diagnosis and Treatment (Current Clinical Neurology), by Steven J. Frucht (Ed.)

Updated and expanded with nine additional chapters, Movement Disorder Emergencies: Diagnosis and Treatment, Second Edition is an indispensable resource for general neurologists, specialists, fellows, and residents eager to improve their approach toward the patient with a movement disorder emergency. In this comprehensive second edition, prominent neurologists from around the world logically and systematically review the major movement disorder emergencies, instructing the reader on how optimally to recognize and manage these problems. The authors cover a broad range of disorders, including acute dystonic reactions, neuroleptic malignant syndrome, startle syndromes, tic emergencies, and others; and they stress the importance of certain obvious diagnoses such as Wilson's disease, dopa-responsive dystonia, and Whipple's disease, in which delayed diagnosis in less emergent situations can lead to slowly evolving and often irreversible neurologic damage with tragic consequences. In addition, nine topics not covered in the first edition are provided, including genetic counseling and testing crises, suicide risk, psychogenic movement disorders, and others. Patient vignettes at the beginning of each chapter focus the reader's attention and highlight the urgency of the problem. Since astute clinical diagnosis of many movement disorders is still largely dependent on visual pattern recognition in the clinic, an accompanying online collection of physician-patient vignettes illustrates virtually all of the movement disorders described in the text. Importantly, the authors also discuss a range of new treatment paradigms that have emerged since publication of the first edition, especially deep brain stimulation. Authoritative and a leading text in the field, Movement Disorder Emergencies: Diagnosis and Treatment, Second Edition is an established, practical reference that continues to achieve excellence in the field of diagnosis and management of movement disorder emergencies.

  • Sales Rank: #2633837 in eBooks
  • Published on: 2012-11-09
  • Released on: 2012-11-09
  • Format: Kindle eBook

Review
"The editors have compiled a unique and excellent review on the challenging topic of movement disorder emergencies...one of the most valuable aspects of this book is the companion CD-ROM...the authors have provided outstanding examples of various rare conditions that are considered movement disorder emergencies...this is a very new and important contribution to the neurologic literature." Weighted Numerical Score: 94 - 4 Stars! - Doody's Health Science Book Review Journal

From the reviews:

"The editors have compiled a unique and excellent review on the challenging topic of movement disorder emergencies...one of the most valuable aspects of this book is the companion CD-ROM...the authors have provided outstanding examples of various rare conditions that are considered movement disorder emergencies...this is a very new and important contribution to the neurologic literature." Weighted Numerical Score: 94 - 4 Stars! - Doody's Health Science Book Review Journal

"In this slim volume, the editors give a brief introduction to movement disorders a ] . This is a nice clinical book directed to a ~front-linea (TM) doctors but with an emphasis I think on those in adult neurology especially those in adult neurology training. Most chapters include clinical vignettes, and at the back of the book is a CD with illustrative videos, an indispensable aid in a subject a ] . I think that the book deserves a place in any hospital that sees emergencies in children." (John B. P. Stephenson, European Journal of Paediatric Neurology, Vol. 10, August, 2006)

"Movement Disorder Emergencies is written for residents, general neurologists, fellows, and specialists in movement disorders. Importantly, much of the information here is not routinely covered in the standard texts on movement disorders, neurological emergencies, or intensive care unit neurology. a ] evolved from the editora (TM)s highly successful course at the annual AAN meeting; if you missed it, or took it but need a refresher, here is a second chance." (Stephen G. Reich and Baltimore, Annals of Neurology, Vol. 58 (5), November, 2005)

From the reviews:

"The editors have compiled a unique and excellent review on the challenging topic of movement disorder emergencies...one of the most valuable aspects of this book is the companion CD-ROM...the authors have provided outstanding examples of various rare conditions that are considered movement disorder emergencies...this is a very new and important contribution to the neurologic literature." Weighted Numerical Score: 94 - 4 Stars! - Doody's Health Science Book Review Journal

"In this slim volume, the editors give a brief introduction to movement disorders . This is a nice clinical book directed to front-line doctors but with an emphasis I think on those in adult neurology especially those in adult neurology training. Most chapters include clinical vignettes, and at the back of the book is a CD with illustrative videos, an indispensable aid in a subject . I think that the book deserves a place in any hospital that sees emergencies in children." (John B. P. Stephen

From the Back Cover
Updated and expanded with nine additional chapters, Movement Disorder Emergencies: Diagnosis and Treatment, Second Edition is an indispensable resource for general neurologists, specialists, fellows, and residents eager to improve their approach toward the patient with a movement disorder emergency. In this comprehensive second edition, prominent neurologists from around the world logically and systematically review the major movement disorder emergencies, instructing the reader on how optimally to recognize and manage these problems. The authors cover a broad range of disorders, including acute dystonic reactions, neuroleptic malignant syndrome, startle syndromes, tic emergencies, and others; and they stress the importance of certain obvious diagnoses such as Wilson's disease, dopa-responsive dystonia, and Whipple's disease, in which delayed diagnosis in less emergent situations can lead to slowly evolving and often irreversible neurologic damage with tragic consequences. In addition, nine topics not covered in the first edition are provided, including genetic counseling and testing crises, suicide risk, psychogenic movement disorders, and others. Patient vignettes at the beginning of each chapter focus the reader's attention and highlight the urgency of the problem. Since astute clinical diagnosis of many movement disorders is still largely dependent on visual pattern recognition in the clinic, an accompanying online collection of physician-patient vignettes illustrates virtually all of the movement disorders described in the text. Importantly, the authors also discuss a range of new treatment paradigms that have emerged since publication of the first edition, especially deep brain stimulation. Authoritative and a leading text in the field, Movement Disorder Emergencies: Diagnosis and Treatment, Second Edition is an established, practical reference that continues to achieve excellence in the field of diagnosis and management of movement disorder emergencies.

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magazine; rolling stone

  • Sales Rank: #9667441 in Books
  • Published on: 2012
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^ Ebook A Bride Sews with Love in Needles, California (Brides & Weddings), by Erica Vetsch

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When her brother is injured fighting in France, Meghan enlists her fellow Harvey Girl waitresses to sew a Red Cross signature quilt to raise money for wounded doughboys. Local horse breeder Caleb McBride longs to join the battle, but the army won’t take him. Because he has kept his shameful infirmity a secret, the townsfolk have labeled him a coward and war profiteer. When Meghan uncovers his malady, her poor opinion of Caleb unravels. Can this beautiful seamstress find a way to mend his heart? 

  • Sales Rank: #548649 in eBooks
  • Published on: 2012-11-01
  • Released on: 2012-11-01
  • Format: Kindle eBook

About the Author

Even though ERICA VETSCH has set aside her career teaching history to high school students in order to homeschool her own children, but her love of history hasn't faded. Erica's favorite books are historical novels and history books, and one of her greatest thrills is stumbling across some obscure historical factoid that makes her imagination leap. She’s continually amazed at how God has allowed her to use her passion for history, romance, and daydreaming to craft historical romances that entertain readers and glorify Him. Whenever she’s not following flights of fancy in her fictional world, Erica is the company bookkeeper for her family’s lumber business, a mother of two, wife to a man who is her total opposite and yet her soul mate, and an avid museum patron.

 

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2 of 2 people found the following review helpful.
Heartwarming Historical Romance
By Keli Gwyn
In a word, A Bride Sews with Love in Needles, California is wonderful! Erica Vetsch has created compelling characters I cared for from the start. I enjoyed every minute spent with impassioned but impulsive Meghan and brave but burdened Caleb. This well-written story is rich in historical detail and will engage the emotions at every turn. I highly recommend it.

0 of 0 people found the following review helpful.
Light and Totally Entertaining!
By Rebecca Maney
Meghan Thornson is ecstatic when she secures employment as a Harvey Girl in Needles, California. A good job, earning her own money, greeting and encouraging World War I recruits, gaining her independence; the perfect combination for success . . . .right?

Caleb McBride keeps to himself, rarely visiting town unless he is required to pick up horses or deliver trained horses to the railroad station for transport. His contributions to the war effort are not appreciated by the residents of Needles, many think he is profiting off the war , rather than volunteering his services; in other words they consider him a coward. And Caleb has done nothing to overtly change those opinions.

When beautiful, outspoken Meghan meets handsome, introverted Caleb, the town of Needles, California may never be the same. Enjoy this light, entertaining look at the brave men and women on the home front during this period of American history.

3 of 3 people found the following review helpful.
Sweet story with some history
By Stephanie Dragon
I'm from Needles, California, so when I saw the title of this book I knew I had to try it. It's a pleasant little book about a young girl who moves to the desert to work as a Harvey Girl in the El Garces Hotel in Needles, during the hotel's glory days. The author has done some homework on the area; readers from Needles will be pleased to see references to real people and places in our community's history. Meghan's effort to help support soldiers while struggling to please a demanding boss, and trying not to fall in love with a man everyone says is wrong for her, makes for a fast, enjoyable read.

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